Sanhita Sinharay has been selected to present an oral presentation at the 2015 World Molecular Imaging Congress, Sep. 2-5, 2015, in Honolulu, HI. She will present on “Pre-screening candidates for Optical Surgical Navigation by detecting GGT enzyme activity with catalyCEST MRI”. Sanhita is completing the final year of her Ph.D. studies in the Department of Chemistry and Biochemistry at the University of Arizona.
Enzymes are significant biomarkers of cancer, hence elucidation of enzyme activity is important. Ovarian cancer is known to overexpress gamma-glutamyl transpeptidase (GGT) enzyme. This research involves the design of a metal-free non-toxic catalyCEST MRI contrast agent that could effectively detect GGT enzyme in ovarian cancer tumors. This noninvasive MRI method is designed to screen patients prior to surgery. This accomplishment is also the first diamagnetic catalyCEST agent to be successfully detected in vivo.
Co-authors: Sanhita Sinharay, Edward Randtke, Kyle Jones, Christine Howison, Setsuko Chambers, Hisataka Kobayashi, Marty Pagel.