Christine Howison

Director of Preclinical Imaging, Contrast Agent and Molecular Engineering Laboratory
Degree(s): 
  • University of Missouri-Columbia  (1994): BS, Animal Science.
Research Interest: 

Christine Howison is the Director of Preclinical Imaging for the Contrast Agent Molecular Engineering Laboratory.  She can help with arranging all aspects of preclinical animal work, protocol generation, and compliance.  

Publications: 
  • Raghunand N, Howison C, Sherry AD, Zhang S, Gillies RJ.  Renal and systemic pH imaging by contrast-enhanced MRI.    Magnetic Resonance in Medicine  (2003),  49(2),  249-257.  PMID: 12541244.
  • Bascunan-Castillo EC, Erickson RP, Howison CM, Hunter RJ, Heidenreich RH, Hicks C, Trouard TP, Gillies RJ. Tamoxifen and vitamin E treatments delay symptoms in the mouse model of Niemann-Pick C.    Journal of applied genetics  (2004),  45(4),  461-7. PMID: 15523158.
  • Correa-Calderon A, Armstrong D, Ray D, DeNise S, Enns M, Howison C.  Thermoregulatory responses of Holstein and Brown Swiss heat-stressed dairy cows to two different cooling systems.    International Journal of Biometeorology.  (2004),  48(3),  142-8. PMID: 14624352.
  • Ahmad I, Lope-Piedrafita S, Bi X, Hicks C, Yao Y, Yu C, Chaitkin E, Howison CM, Weberg L, Trouard TP, Erickson RP.  Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.    Journal of Neuroscience Research.  (2005),  82(6),  811-821. PMID: 16273542. 
  • Morse DL, Raghunand N, Sadarangani P, Murthi S, Job C, Day S, Howison C, Gillies, RJ.  Response of choline metabolites to docetaxel therapy is quantified in vivo by localized 31P MRS of human breast cancer xenografts and in vitro by high-resolution 31P NMR spectroscopy of cell extracts.    Magnetic Resonance in Medicine. (2007), 58(2), 270-280, PMID: 17654590.
  • Sheth VR, Liu G, Li Y, Howison CA, Flask CA, Pagel MD.  Measuring In Vivo Tumor pHe with CEST-FISP MRI.  Magnetic Resonance in Medicine. (2012), 67:760–768, PMID: 22028287.
  • Cardenas-Rodriquez J, Howison CM, Pagel MD.  A linear algorithm of the reference region model for DCE-MRI is robust and relaxes requirements for temporal resolution.  Magnetic Resonance Imaging. (2013), 31(4), 497-507. PMID: 23228309.
  • Yoo B, Sheth VR, Howison CM, Douglas MJK, Pineda CT, Maine EA, Baker AF, Pagel MD.  Detection of in vivo enzyme activity with CatalyCEST MRI.  Magnetic Resonance in Medicine. (2014).  PMID: 23640714.
  • Yoo B, Sheth VR, Howison CM, Douglas MJK, Pineda CT, Maine EA, Baker AF,  Pagel MD.  Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI.  Magnetic Resonance in Medicine. (2013),  DOI: 10.1002/mrm.24763.  
  • Cardenas-Rodriquez J, Howison CM, Matsunaga TO, Pagel MD.  A reference agent model for DCE MRI can be used to quantify the relative vascular permeability of two MRI contrast agents.  Magnetic Resonance Imaging (2013).  31(6), 900-910.  PMID:  23583323.
  • Chen LQ,  Howison, CM, Randtke EA, Robey IF, Howison CM, Kuo P, Jeffery JJ, Pagel MD.  Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI.  Magnetic Resonance in Medicine (2013). DOI: 10.1002/mrm.25053
  • Jones KM, Randtke EA, Howison CM, Cardenas-Rodriguez J, Sime PJ, Kottmann MR, Pagel MD.  Measuring   extracellular pH in a lung fibrosis model with acidoCEST MRI.  Molecular Imaging and Biology.  (2014).  DOI: 10.1007/s11307-014-0784-6.
  • Chen LQ, Howison CM, Spier C, Stopeck AT, Malm SW, Pagel MD, Baker AF.  Assessment of carbonic anhydrase IX expression and extracellular pH in B-cell lymphoma cell line models.  Leukemia and Lymphoma.  (2014).  DOI:10.3109/10428194.2014.933218.
  • Chen LQ, Randtke EA, Jones KM, Moon BF, Howison CM, Pagel MD.  Evaluations of tumor acidosis within in vivo tumor models using parametric maps generated with acidoCEST MRI.  Molecular Imaging and Biology.  (2015).  DOI: 10.1007/s11307-014-0816-2.
  • Kobes JE, Daryaei I, Howison CM, Brontrager JG, Sirianni RW, Meuillet EJ, Pagel MD.  Improved treatment of pancreatic cancer with drug delivery nanoparticles loaded with a novel AKT/PDK1 inhibitor.  Pancreas.  (in press).
  • Moon BF, Jones KM, Chen LQ, Liu P, Randtke EA, Howison CM, Pagel MD.  A comparison of iopromide and iopamidol, two acidoCEST MRI contrast media that measure tumor extracellular pH.  Contrast Media and Molecular Imaging (2015 in press).
Phone: 
520-903-1552