Paul Joseph Akhenblit

Graduate Research Associate, Cancer Biology Graduate Interdisciplinary Program
Degree(s): 
  • Arizona State University, B.S. Biochemistry, 2011.
Research Interest: 

I am interested in two primary focuses. Firstly, I am interested in targeting the reprogrammed cellular metabolism in cancer cells with therapies. I believe metabolism-targeting agents will have added synergistic effect when combined with traditional chemotherapeutic agents. Secondly, I want to keep developing imaging (or otherwise non-invasive) methods and models for predicting or measuring tumor response to drug therapies. I am currently investigating extracellular tumor pH as a biomarker for drug response to metabolism-inhibiting agents using an MRI imaging method. Similarly I would like to develop complementary imaging methods and models to serve as diagnostic platforms in the clinic. It is my passion to see new methods decrease the delay between administering initial treatment and detecting a measurable tumor response, or lack thereof, to quickly determine the best course of treatment on a case by case basis. I believe until new tools and drugs are developed to better treat patients, optimizing tumor management is the next incremental step in increasing patient survival outcome.

Awards: 
  • 2015 Cancer Biology Training Grant T32CA009213, Accepted.
  • 2015 Biomedical Imaging and Spectroscopy Fellowship, Declined.
  • 2013 Anne Rita Monahan Foundation Scholarship.
  • 2008 Arizona State University Provost Merit Scholarship.
  • 2008 Arizona State University Science Technology Engineering Math Scholarship.
Publications: 
  • K.J. Koski, K. McKiernan, P. Akhenblit and J.L. Yarger, “Non-invasive determination of the complete elastic moduli of spider silks” Nature Materials, Advanced online publication (2012).
  • K.J. Koski, K. McKiernan, P. Akhenblit and J.L. Yarger, “Shear-indced rigidity in spider silk glands”,Appl. Phys. Lett. (2012).
  • Izdebski T, Akhenblit P, Jenkins JE, Yarger JL, Holland GP, “Structure and Dynamics of Aromatic Residues in Spider Silk: 2D Carbon Correlation NMR of Dragline Fibers” Biomacromolecules (2010).

Poster Presentations:

  • Paul J. Akhenblit, Christine M. Howison, Mark D. Pagel Assessing Changes in Tumor Extracellular pH during Metabolism-Targeting Therapies with acidoCEST MRI WMIC Annual Meeting, Honolulu, HI, September 2015.
  • Paul J. Akhenblit, Christine M. Howison, Scott W. Malm, Liu Qi Chen, Amanda F. Baker, Mark D. Pagel.
  • “Monitoring Early Therapeutic Response by Measuring Extracellular pH in a Tumor Model with acidoCEST MRI”.
  • WMIC Annual Meeting, Seoul, South Korea, September 2014.
  • Paul J. Akhenblit, Christine M. Howison, Scott W. Malm, Liu Qi Chen, Amanda F. Baker, Mark D. Pagel.
  • “Monitoring Early Therapeutic Response by Measuring Extracellular pH in a Tumor Model with acidoCEST MRI”.
  • AACR Annual Meeting, San Diego CA, April 2014. 
Phone: 
520-345 6797